Glossary: Synthesis

Selection of synthetic methods:

aldol-condensation

aromatic substitution

SN-reaction

fluorination

esterification

(de-) acylation

(de-) etherfication

glycosylation

chiral-pool enantioselective reactions

N-/O- alkylation/dealkylation

nitration

diazotation

metallorganic bases

metall-catalyzed cross coupling

(de-) halogenation

reduction

hydrogenation

oxidation

(N-, O-, etc.) protection/deprotection

aromatic formylation

Claissen-rearrangement

Picet-Spengler-reaction

Mitsunobu-reaction

Sandmeyer-reaction

Ullmann-reaction

Suzuki-reaction

Wittig-Horner-reaction

Vilsmeier-reaction

Swern-oxidation

Gabriel-reaction

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Glossary: MedChem projects

Examples of
conducted projects:

Natural product synthesis melatonin inhibitor, 1 g, 10-step regioselective synthesis

12 building blocks, 10 g each, 2-step synthesis including cross coupling

10 N-heterocycles, 100 mg each, 4-step synthesis, patent verification

7 pyrolidines, 3 g each, 4-step enantioselective synthesis d.e.>90%

3 building blocks, 100 g each, 2-step synthesis

thiazolines, 1 g, 3-steps, compounds for FDA stability test

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Glossary

Integrated Medicinal Chemistry makes your leads move on fast

Drug discovery and development is an interdisciplinary field and needs expertise in many different areas. Based on strong synthetic execution skills for natural products and a deep knowledge of key factors in drug discovery, Bicoll provides integrated medicinal chemistry services.

We seamlessly guide your Synthesis and Lead Optimization projects through drug discovery and development with intensive understanding of structure-activity relationships, capability in biological data interpretation, solid knowledge of intellectual property and patent aspects and reliable and fast reporting under your specific requirements.

Bicoll's Medicinal Chemistry Facilities China

Project management for your MedChem inquiries is executed at our Munich location. Our experienced European team guarantees secure handling of confidential biological data and provides MedChem support through skilled chemists for your projects.

Synthesis and chemical development of your MedChem projects are executed at our Shanghai laboratories. State-of-the-art equipment and experienced chemists enable Bicoll to meet your expectations.

MedChem at Bicoll Munich

Project management

Handling and interpretation of confidental biological data

MedChem consulting

Reporting and Communication

Project meetings and conference calls

MedChem at Bicoll Shanghai

State-of-the-art synthesis through skilled chemists

Literature search and route scouting

Analytical reports

Selection of synthetic methods:

Examples ofconducted projects:

Integrated Medicinal Chemistry makes your leads move on fast

MedChem at Bicoll Munich

MedChem at Bicoll Shanghai

Examples of
conducted projects: