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By utilizing rare plants, Bicoll has chosen the most successful source of drugs to set up its drug like compounds library BILOBAC N. The molecules are legally obtained by Bicoll's publicly and scientifically respected sustainable method from endemic plants coming from biological highly diverse areas in Asia. Within its plant supply network Bicoll guarantees reproducible scientific survey and collection including GPS positioning, digital photo and Herbarium voucher. Certain collected data on plants is processed also within the BIFLORATM database. Bicoll's continously increasing stock includes more than 2000 plant extracts at present time. These extracts represent the foundation of high-quality, evolutionary optimized small molecule libraries.
BIFRAC N, Bicoll's efficient novel deconvolution and isolation strategy enables the company to provide customers, as well as its own drug development programs, with unique sets of compounds. BIFRAC N facilitates Bicoll to have full access to all kinds of small, bioactive molecules from natural resources in a quality, which fits to be utilized in standard high throughput screening.
Key features of the profile library obtained by BIFRAC N technology: > Huge structural diversity of bioactive compounds > Known sample concentrations > Gentle separation conditions give access to new, patentable structures > Orthogonal separation technologies guarantee fast isolation of pure compounds > Fast and easy scale up for redelivery of larger compound amounts Up to 192 profiles (fractions) can be produced from one plant. Their outstanding quality is secured by standardized routine checks and additional spot-checks by conventional HPLC methods. At its research locations in Shanghai and Munich, Bicoll has access to state of the art analytical methods including NMR, RP-HPLC(DAD/ELSD), LC-MS. These facilities in combination with Bicoll's experts and technology secure fast structure elucidation of hits, as well as fast supply of selected hits in sufficient amounts for further development. |
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